45 E Main Street offers 900 sq ft of newly updated retail/office space positioned at the strategic intersection of US 75 and 136, providing exceptional visibility and access to transient traffic. The space features updated interior finishes, new HVAC system, one bathroom, and ample parking and loading access. The building's first floor totals 3,456 sq ft, with an additional 2,556 sq ft available for negotiation-ideal for phased expansion, storage, or future buildout. Jamestown's neighborhood is experiencing active population growth, creating strong fundamentals for small business operations. First-year lease rate is $500/month (utilities $100/month additional), with fully negotiable lease terms tailored to qualified tenants. The combination of highway visibility, neighborhood momentum, flexible space options, and introductory pricing creates an attractive entry point for small business operators seeking established infrastructure and growth trajectory. Move-in ready.